Measuring Metabolic Changes in Diseased Fibroblasts Associated with Mitochondrial DNA Deletions and Mutations

Insights: Events Measuring Metabolic Changes in Diseased Fibroblasts Associated with Mitochondrial DNA Deletions and Mutations

Cold Spring Harbor Laboratory, The Evolving Concept of Mitochondria Meeting

Since it was first observed within cells at the end of the nineteenth century, our bacterial endosymbiont, the mitochondrion, has been interrogated from many perspectives. Initially described as a cytoplasmic structure, then as the source of energy, later an organismal entity, and recently a component of many diseases, the multi-faceted mitochondrion has engendered fascination from a broad spectrum of physical, chemical, biological, and medical perspectives. What is this cell-within-a-cell? Where did it come from? What is its relevance to our health and well being? How will mitochondrial knowledge affect the future? These are the questions we hope to discuss in this stimulating meeting of modern mitochondriacs who will discuss past, current state and future prospects through their important contributions to the field.